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Révision datée du 1 juin 2023 à 09:10 par DeangeloMcCready (discussion | contributions) (Page créée avec « <br>13. Gaziano JM, Glynn RJ, Christen WG, et al.: Vitamins E and C in the prevention of prostate and complete most cancers in adult males: the Physicians' Health Study II… »)
13. Gaziano JM, Glynn RJ, Christen WG, et al.: Vitamins E and C in the prevention of prostate and complete most cancers in adult males: the Physicians' Health Study II randomized managed trial. 23. Klein EA, Sex Chat Room Thompson IM, Tangen CM, et al.: Vitamin E and the threat of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (Select). Toenail selenium ranges had been assayed in a two-situation cohort review of a subset of Select members. Findings from 28 decades of comply with-up of the cohort verified the deficiency of affiliation concerning serum alpha-tocopherol degrees and prostate cancer possibility. Baseline serum alpha-tocopherol degrees and nutritional consumption of vitamin E had been assessed and members have been monitored for up to 19 yrs. Participants were being randomly assigned to obtain vitamin E (synthetic alpha-tocopherol, 400 IU qod) and/or vitamin C (synthetic ascorbic acid, 500 mg/d) dietary supplements and ended up monitored for an common of eight years. Chemical standardization is commonly performed with organic extracts, as a means of improving the reproducibility of research with herbal nutritional supplements via qualitative and quantitative chemical analysis. The natural components in this complement had been raw, dry, powdered plant components and 1 plant extract, none of which were being chemically standardized
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In a 2009 research, blood samples received from members in the ATBC Study were being analyzed and genotyped. On the foundation of the outcomes of the ATBC Study, all-rac-alpha-tocopheryl acetate was the variety of vitamin E made use of in Select. Another essential variance concerning the ATBC Study and Select that may perhaps clarify the findings was the using tobacco position of research individuals. A research of serum metabolomic response to vitamin E supplementation observed that substantial-dose (400 IU/d) but not lower-dose (50 IU/d) vitamin E resulted in a significant reduction in a novel C22 lactone sulfate that was highly correlated with alterations of androgenic steroid metabolites, possibly describing the discordant outcomes of the two trials. More than 35,000 adult males, aged 50 a long time or older, from far more than four hundred analyze websites in the United States, Canada, and Puerto Rico have been randomly assigned to get vitamin E (all-rac-alpha-tocopherol acetate, 400 IU/d) and a placebo, selenium (L-selenomethionine, two hundred µg/d) and a placebo, vitamin E and selenium, or two placebos day-to-day for seven to 12 years
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