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LF, Lactoferrin lactotransferrin SARS-CoV, acute respiratory syndrome coronavirus LRP-1/CD91, LDL receptor-linked protein-1 TLR2 and 4, Toll-like receptor 2 and four CXCR4, cytokine receptor four GAG, glycosaminoglycan AP-1, activator protein 1 NF-κB, NF-kappa beta IRF, Interferon regulatory component MAPK, Mitogen-activated protein kinase HSPG, Heparan sulfate proteoglycans ACE2, Angiotensin-converting enzyme 2 IL, Interleukin G-CSF, Granulocyte colony-stimulating component GM-CSF, Granulocyte-Macrophage Colony Stimulating Component IFN, Interferon TNFα, Tumor necrosis component alpha IP10, Interferon gamma-induced protein ten MCP1, Monocyte Chemoattractant Protein-1 (MIP1) A and B, Macrophage inflammatory protein one (A and B) LMWH, Low molecular bodyweight heparin vWF, von Willebrand Component PAD4, protein arginine deiminase four NETS, Neutrophil extracellular traps. These indicators are linked with a cytokine storm (166, 167) manifesting elevated serum amounts of interleukin (IL) IL-1β, IL-2, IL-7, IL-8, IL-9, IL-10, IL-17, granulocyte colony-stimulating component (G-CSF), Granulocyte-Macrophage Colony Stimulating Component (GM-CSF), interferon (IFN)γ, tumor necrosis component (TNF)α, Interferon gamma-induced protein ten (IP10), Monocyte Chemoattractant Protein-1 (MCP1), macrophage inflammatory protein 1(MIP1)A and MIP1B (168). IL-22, in collaboration with IL-17 and TNFα, induces antimicrobial peptides in the mucosal organs. 8. Hondermarck H, Bartlett NW, Nurcombe V. The job of advancement component receptors in viral bacterial infections: an possibility for drug repurposing in opposition to emerging viral conditions these kinds of as COVID-19? FASEB Bioadv

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