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"The President's Role in Advancing Criminal Justice Reform" (PDF). Purtill, James (September 4, 2017). "Burning Man eyewitness describes horrific pageant demise". White House. December 8, 2003. Archived from the initial on October 6, 2013. Retrieved September 1, 2008 - by way of National Archives. Dunsworth HM (September 2010). "Origin of the Genus Homo". Arthur, Charles Kiss, Jemima (July 21, 2010). "Facebook reaches five hundred million end users". Claburn, Thomas (January 16, 2013). "Meet Facebook's Graph Search Tool". 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This syndrome normally takes place only right after ingestion of substantial amounts of caffeine, effectively around the amounts discovered in typical caffeinated beverages and caffeine tablets (e.g., much more than 400-500 mg at a time). Caffeine's organic fifty percent-lifestyle - the time required for the human body to eradicate 1-50 percent of a dose - differs commonly amid individuals in accordance to elements this kind of as being pregnant, other medicine, liver enzyme perform amount (desired for caffeine metabolism) and age. Cigarette smoking induces the cytochrome P450 1A2 enzyme that breaks down caffeine, which may possibly guide to amplified caffeine tolerance and espresso intake for standard smokers. Caffeine, as do other alkaloids these types of as cinchonine, quinine or strychnine, precipitates polyphenols and tannins. The differing perceptions in the outcomes of ingesting beverages created from a variety of plants that contains caffeine could be stated by the point that these drinks also have various mixtures of other methylxanthine alkaloids, which include the cardiac stimulants theophylline and theobromine, and polyphenols that can type insoluble complexes with caffeine. Firstly, in the cell vacuoles where it is complexed with polyphenols